» » Genomic Regulatory Systems: In Development and Evolution
Download Genomic Regulatory Systems: In Development and Evolution epub book
Author: Eric H. Davidson
ISBN13: 978-0122053511
Title: Genomic Regulatory Systems: In Development and Evolution
Format: lrf rtf docx lrf
ePUB size: 1534 kb
FB2 size: 1623 kb
DJVU size: 1809 kb
Language: English
Category: Biological Sciences
Publisher: Academic Press; 1st edition (January 25, 2001)
Pages: 261

Genomic Regulatory Systems: In Development and Evolution by Eric H. Davidson

Start by marking Genomic Regulatory Systems: In Development and Evolution as Want to Read: Want to Read savin. ant to Read.

If you really want to understand what is known about DNA transcription, you will first get a 500 level background in cell biology and biochemistry. After reading Genomes 3 by TA Brown (very good) you will hav a 600 level understanding. But no sooner had I opened that door and begun to survey the landscape than, as in an old legend of magic, everything seemed to have been transformed to another landscape. But development is the output of regulatory systems comprising large numbers of regulatory genes.

San Diego (California): Academic Press. xii + 261 p; il. index. Alan Kumar and Sudhir Kumar. Biology, Arizona State University, Tempe, Arizona. Alan Rawls and Sudhir Kumar, "Genomic Regulatory Systems: Development and Evolution.

Eric Harris Davidson (April 13, 1937 – September 1, 2015) was an American developmental biologist at the California Institute of Technology. Davidson was best known for his pioneering work on the role of gene regulation in evolution, on embryonic specification and for spearheading the effort to sequence the genome of the purple sea urchin, Strongylocentrotus purpuratus. Genomic Regulatory Systems: Development and Evolution (2001). Rast; P. Oliveri; et al. (2002). A genomic regulatory network for development". The Regulatory Genome: Gene Regulatory Networks In Development And Evolution (2006).

Author : Eric H. Davidson. Publisher : Academic Press. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist.

Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship.

Genomic Regulatory Systems. In Development and Evolution. Authors: Eric Davidson. eBook ISBN: 9780080525594. Imprint: Academic Press. The discussions and conceptual explorations occasioned by this collaboration produced the new synthetic views encompassed in this book, building on decades of earlier work summarized in the 2001 and 2006 Academic Press books by Eric H. Affiliations and Expertise. Norman Chandler Professor of Cell Biology, California Institute of Technology, Pasadena, CA, USA.

The Regulatory Genome: Gene Regulatory Networks In Development And Evolution. In this book, without immersing the reader in descriptive details, selected recent results from a great variety of animal model systems are embedded in a conceptual resolution of the control logic underlying the developmental process, and of the changes in that logic by which evolution of the body plan occurs.

The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest.The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist. * Contents Include* Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution * Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression* Regulation of Direct Cell-Type Specification in Early Development* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
Reviews: 6
I've always loved this book. I purchased this copy used, and it came from the vendor in good (as advertised) condition. Re-re-reading it, I see that some of the research behind it is starting to look a little dated (rather, we have more data now, not that it is necessarily incorrect on any particular point), but it's still a very nice introductory book to the subject.
The book itself is terrific. It's not really introductory, but is an excellent, well organized overview of the topic. Some of it is already a bit dated (e.g., estimates of the number of human genes) but these gaps hardly detract from the overall value: the principles of evo-devo are better articulated here than just about any other source I know. However, the excellent examples depend heavily on the figures, which are not reproduced in color in the Kindle edition. That is, I can read some Kindle books on my Mac or iPad, and the figures are in color, but for THIS book they are in black and white). This is a terrible loss, because the beautiful figures are essentially uninterpretable in black and white.
This is a very intersting book on an amazing topic which is straightforward enough for an interested educted layman to understand. But unfortunately it is a wierd mix of chatty remarks and pointlessly obstruse passages that read like letters to Nature.

The very worst thing is the illustrations and blurbs. The design is so bad that it really is hilarious at times. Sometimes the blurbs are so long they are spread onto the next page. The contain three or four different fonts in the same sentence. The sources of the information are pointless mixed with non-technical information about the content...

There is no logic in the way "subillustrations" are combined to illustrations. (Why do they insist on subillustrations at all? Why not make separate illustration?) They are just slapped together any old way. Sometime there are additional frams, sometimes not. Even the numbering convention varies. The order that the subillustration appear in the illustrations is also random.

The book is almost impossible to read. It needs to go back to the publisher and be totally reorganized for readability.

What a pity. The content is actually fascinating.
On the back of this book's cover we read, "authoritative and easy to read". We may grant the first, but hardly the second. Davidson has worked for a long time at the cutting edge of cell-biological research, and makes it quite clear that our knowledge of the process by which the genes produce the organism they give rise to, is far from complete. Presenting numerous interesting examples, always supported by excellent illustrations, he offers us a fascinating sketch of the way the genetic DNA material in the chromosomes is translated into a developmental process in the organism, from fertilized egg to adult. He carries us far beyond the revolutionary ideas in Darwin's "Origin of Species" from 1859, and also beyond the "Neo-Darwinians", whose ideas on evolution and development dominated most of the 20th century. Not being a biologist, but rather a historian of ideas, predominantly in the field of natural science, I am impressed by the recent advances in biology after Crick's and Watson's discovery of the DNA double spiral as the material basis of the genome. We might say that the Neo-Darwinists, like Darwin himself, regarded the genes as fairly independent "elements", or "atoms" of heredity, each responsible for its own part (or characteristic trait) of the organism. The essentially random variation of those elements provided the raw material for Natural Selection, and thereby Evolution. That was also for a long time my own view. This book has forced me to adopt a new perspective. However, it seems to me that the "elemental" view of the genes has an entrenched position among the general public, who use it in arguments both for and against the Darwinian theory of Evolution by Natural Selection. Davidson insists that the genes are by no means independent elements. They are very much dependent on each other. In particular, a rather limited number of them, which he calls regulatory genes, are especially important in evolution (and of course also in the development from the fertilized egg to the adult). He also stresses very strongly that the characteristics of an organism are not at all the creation of individual genes, but of a considerable number of genes working in concert, to a large extent orchestrated by the regulatory genes. Thus the whole process stands out as much more powerful, but also as extremely complicated. This is as it should be: who would deny that life is a complex phenomenon? To anybody interested in Evolution -- and in Man's place in Nature -- Davidson's book provides much food for thought. But note: unless you have a good grounding in biology, do not expect an "easy read".
This book is complementary too, but on a more advanced level than Sean Carroll's From DNA To Diversity, which I strongly recommend as a great intro book to evo-devo. Davidson's book is tough going in places, which is why I gave it one star off, but the material is in fairness quite complex. He emphasizes the role of cis-regulatory sequences in genes and the structure of the systems that regulate gene expression in development and evolution in some detail. It becomes clear how minor mutations in the regulatory part of a gene can transform how it is expressed, and why the importance for evolution in mutations in gene expression is clearly much greater than for mutations in the protein coding sequence. His explanation for what is responsible for the incredible homologies in, for example, the pax 6 gene that regulates eye development across phyla is very illuminating. A must read for anybody interested in the molecular basis for development and evolution.