Trypanosomes: After the Genome Hardcover – 21 Dec 2006.
Trypanosomes: After the Genome. David Barry, Richard McCulloch, Jeremy Mottram, Alvaro Acosta-Serrano. Taylor & Francis Published December 21, 2006 Reference - 250 Pages - 33 B/W Illustrations ISBN 9781904933274 - CAT RU3270Z. The publication of the genome sequences of two key trypanosomes, Trypanosoma brucei and Trypanosoma cruzi, in 2005 has provided an exciting new resource to improve our understanding of the molecular and cellular biology of these important parasites and aid the development of new drugs and vaccines. The genome sequences, allied with useful genetic tools and easy molecular manipulation, will consolidate T. brucei as a eukaryotic model organism. As a model, it has the added advantage that studies in this area are directly applicable to understanding and prevention of disease. Download PDF of entire book. Trypanosomes cause medically and economically severe diseases such as Sleeping Sickness and Chagas' Disease in humans and Nagana in cattle.
Taylor & Francis. 250 pages 33 B/W Illus. As a model, it has the added advantage that studies in this area are directly applicable to understanding and prevention of disease
Trypanosomes, After the Genome (ed. D. Barry, R. McCulloch, J. Mottram and A. Acosta-Serrano), pp. 423. Horizon Bioscience, Wymondham, Norfolk, UK. ISBN 13:978-1-904933-27-4.
The ~160 Mb genome was found to be significantly larger than first described, presenting new challenges to the standard genome sequencing pipeline, as well as to continued funding. Here we present an overview of the project, including both a historical synopsis of how the project was conceived and carried out, as well as a summary of the fascinating biology revealed by analysis of the genome. To illustrate the utility of the complete genome sequence, specific areas of the parasite's biology - including membrane trafficking and mode of reproduction - are expanded and brought up-to-date
by David Barry, Richard McCulloch, Jeremy Mottram, Alvaro Acosta-Serrano. Trypanosomes cause medically and economically severe diseases such as Sleeping Sickness and Chagas’ Disease in humans and Nagana in cattle. They are also inherently interesting scientifically, being single-cell eukaryotes under. The African Trypanosomes (World Class Parasites). by Samuel J. Black, J. Richard Seed. African trypanosomes are tsetse-transmitted protozoa that inhabit the extracellular compartment of host blood
Trypanosomes After the Genome. Great Britain: Horizon Bioscience. Trypanosomes live extracellularly in both the tsetse fly and the mammal. Trypanosome surface proteins can directly interact with the host environment, allowing parasites to effectively establish and maintain infections. inositol (GPI) anchoring is a common posttranslational modification associated with eukaryotic surface proteins. In T. brucei, three GPI-anchored major surface proteins have been identified: variant surface glycoproteins (VSGs), procyclic acidic repetitive protein (PARP or procyclins), and brucei alanine rich proteins (BARP).
African trypanosomes, such as Trypanosoma brucei, are protozoan parasites of mammals that were first described over 100 hundred years ago. They have long been the subjects of biological. McCulloch . Vassella . Burton . Boshart . Barry . 2004) Transformation of Monomorphic and Pleomorphic Trypanosoma brucei. eds) Genetic Recombination. Methods in Molecular Biology™, vol 262.