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ISBN:3540576339
Author: Maurizio Ponz de Leon
ISBN13: 978-3540576334
Title: Familial and Hereditary Tumors (Recent Results in Cancer Research)
Format: txt lit mbr lrf
ePUB size: 1200 kb
FB2 size: 1627 kb
DJVU size: 1614 kb
Language: English
Category: Medicine and Health Sciences
Publisher: Springer; 1 edition (November 29, 1994)
Pages: 349

Familial and Hereditary Tumors (Recent Results in Cancer Research) by Maurizio Ponz de Leon



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During the last 20–30 years, a large body of epidemiologic, cytogenetic, and experimental studies have supported the hypothesis that tumors are caused by genetic damage. Ponz de Leon M, Roncucci L, Di Donato P et al. (1988) Pattern of epithelial cell proliferation in colorectal mucosa of normal subjects and of patients with adenomatous polyps or cancer of the large bowel. Cancer Res 48:4121–4126Google Scholar.

Thus, the idea that some common human malignancies could be transmitted from one generation to another with features of mendelian gene tics became more and more evident

Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies. This volume provides a general overview of the latest developments in angiogenesis inhibition in cancer. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins  . This book will be invaluable to all who wish to learn of the most recent advances in this exciting field.

Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 167:13-36 · February 2006 with 27 Reads. DOI: 1. 007/3-540-28137-1 2 · Source: PubMed. Cite this publication. A total of 350 patients with primary and secondary liver tumors have already successfully been treated with stereotactic radiofrequency ablation (SRFA). Due to its low complication rates and similar local recurrence and survival rates as compared to conventional surgery SRFA is an attractive alternative for the treatment for primary and secondary liver tumors.

Attempts to influence survival of patients with colorectal cancer (CRC) by adjuvant chemotherapy are limited by the variability of survival in different prognostic groups and the paucity of drugs that have shown activity in the advanced disease. Of the few drugs which are active in the advanced disease.

Maurizio Ponz de Leon. Recent Results Canc Res. M Ponz de Leon. Colorectal cancer is a major cause of death in Western countries and one of the neoplasms in which the contribution of heritable factors has been investigated in more detail, in terms of both genetic epidemiology and molecular biology.

Each article will be written by an expert in the field of retrovirology. From the Back Cover Retroviruses cause chronic infections and insertion mutations in their hosts, often leading to the appearance of tumors.

For many years the etiology of human tumors has almost exclusively been attributed to environmental factors, which seemed to be involved not only in the induction of neo­ plasms but also in other phases of tumorigenesis. Cigarette smoking and alcohol are the two best known examples of factors related to our modern lifestyle which have been implicated in the development of cancer of various organs. From the 1960s onward, the pioneer work of a few investigators clearly showed that hereditary factors were not only related to rare neoplasms, but could also be respon­ sible for the occurrence of a sizeable fraction of tumors that do not usually show features of inheritance (as in the case of breast or colorectal cancer). Thus, the idea that some common human malignancies could be transmitted from one generation to another with features of mendelian gene­ tics became more and more evident. In addition, the verit­ able explosion of molecular biology in the last 15 years has made a further and substantial contribution to the emerging role of genetics in biomedical research and particularly in cancer.