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ISBN:0792389808
Author: A.M. Gressner,G. Ramadori
ISBN13: 978-0792389804
Title: Molecular and Cell Biology of Liver Fibrogenesis (Falk Symposium)
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ePUB size: 1454 kb
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Language: English
Category: Medicine
Publisher: Springer; 1992 edition (September 30, 1992)
Pages: 576

Molecular and Cell Biology of Liver Fibrogenesis (Falk Symposium) by A.M. Gressner,G. Ramadori



This book appeared within less than 12 months of the symposium. It. is well illustrated, and the photomicro-graphs, almost all in black and white, have reproduced well and demonstrate what they are intended to dem-. Molecular and Cell Biology. of. Liver Fibrogenesis. Gressner and G. Ramadori, 555 pp. cannot be faulted. Since the pioneering work of Crystal. Fibrogenesis is a beneficial effect of wound healing. In liver disease, however, fibrogenesis often leads to dis-ability and death. The control of these processes, intracel-lular synthesis and distributions between intracellular degradation and export could be a topic of a future symposium.

Molecular and cell biology of liver fibrogenesis. Dordrecht: Kluwer Academic Publishers, 145–151, 1992. Gressner AM: Time related distribution profiles of sulfated gly- cosaminoglycans in cells, cell surfaces and media of cultured rat liver fat-storing cells. 196:307–314, 1991Google Scholar. 24. Gressner AM, PazenH and GreilingH: The synthesis of total and specific glycosaminoglycans during development of experimental liver cirrhosis. Experientia 33:1290–1292, ogle Scholar. 25. Gressner AM and Köster-EiserfunkeW: Proteoglycans in experimental liver diseases. In:Popper H, Reutter W, Gudat F, KöttgenE, eds. Structural carbohydrates of the liver. Dordrech t, The Netherlands: Kluwer Academic Pub- lishers, 1992. In liver disease, however, fibrogenesis often leads to dis- ability and death. The extent of the harmful effect is determined by the unique cellular architecture of the liver, the prolonged action of the injurious agent, the ability of the liver to generate a number of different extracellular matrix components and the heterogeneous cellular composition of the liver. This book appeared within less than 12 months of the symposium. It is well illustrated, and the photomicro- graphs, almost all in black and white, have reproduced well and demonstrate what they are intended to dem- onstrate. Given the objectives of the symposium, the book cannot be faulted.

Liver cell cultures and fibrogenesis. Fig 5. Analysis of cell functionality of CFSC-2G, primary hepatocytes, and cocultures. In Molecular and Cellular Biology of Liver Fibrogenesis. AM Gressner, G Ramadori (eds). Kluwer, Lancaster, UK, 1992, pp 85–98. 36. Lore´al O, Levavasseur F, Fromager C, Gros D, Guillouzo A, Cle´ment B: Cooperation of Ito cells and hepatocytes in the deposition of extracellular matrix in vitro.

Home All Categories Molecular and Cell Biology of Liver Fibrogenesis (Falk Symposium). ISBN13: 9780792389804. Molecular and Cell Biology of Liver Fibrogenesis : Proceedings of the International Falk Symposium Held in Marburg, Germany, 22-23 January 1992. This volume, the proceedings of the International Falk Symposium held in Marburg, Germany, in January 1992, summarizes the most recent advances in the study of cellular and molecular mechanisms of fibrosis provided by contributions from the leading scientists in this field. Proceedings of the International Falk Symposium Held in Marburg, Germany, 22-23 January 1992. Author: A. M. Gressner,G. Publisher: Kluwer Academic Pub. ISBN: . It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies.

In: Gressner AM, Ramadori G (eds). and Cell Biology of Liver Fibrogenesis. demic Publishers: Dordrecht, 1992, pp 373–384. 27 Mak KM, Leo MA, Lieber CS. Alcoholic liver injury in. baboons: transformation of lipocytes to transitional. 37 Ramadori G. The stellate cell (Ito-cell, fat-storing cell, lipocyte, perisinusoidal cell) of the liver. into pathophysiology of an intriguing cell. Arch B Cell Pathol Incl Mol Pathol 1991;61:147–158. 38 Seifert WF, Roholl PJ, Blauw B, et al. Fat-storing cells.

During the last few years, considerable progress has been made in the dissection of cellular and molecular mechanisms of hepatic fibrogenesis. The disease, initiated by hepatocellular damage and perpetuated by inflammatory reactions, results not only. Perisinusoidal fat (retinoid)-storing cells have been identified as the (precursor) cell type mainly responsible for matrix production in the diseased liver. However, these cells have to be activated, . stimulated to proliferate, to transform phenotypically to myofibroblasts and to express matrix genes before full competency for fibrogenesis is reached.

Gressner AM, Bachem MG: Molecular mechanisms of liver fibrogenesis – a homage to the role of activated fat-storing cells. View ArticlePubMedGoogle Scholar. Jaster R, Hilgendorf I, Fitzner B, Brock P, Sparmann G, Emmrich J, Liebe S: Regulation of pancreatic stellate cell function in vitro: biological and molecular effects of all-trans retinoic acid.

Experimental models of liver fibrosis/cancer and future directions. The models existing in literature are not completely accurate and do not entirely recreate the human conditions: the limitations are mainly related to the lack of a tool that could summarize all the features in a single experimental model. Kisseleva T, Brenner DA. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis Brenner DA, Seki E, Taura K, et al.

This volume, the proceedings of the International Falk Symposium held in Marburg, Germany, in January 1992, summarizes the most recent advances in the study of cellular and molecular mechanisms of fibrosis provided by contributions from the leading scientists in this field. It updates our knowledge on the basic components of fibrosis, on the cellularorigin and degradation of matrix components, on peptide and non-peptide mediators, cellular cooperation and other mechanisms of fibrogenesis, on the role of the extracellular matrix as modulator of fibrogenesis, and on some aspects of antifibrotic trials and biochemical monitoring of the development of fibrosis. Since liver fibrogenesis has, to a certain extent, attained the status of a model for fibrotic tissue reactions that occur generally in various organs and tissues, the fundamental processes described here may be relevant for other sites of tissue repairs and fibrosis, for would healing and even for atherogenesis.