|Author:||Frances M. Ashcroft|
|Title:||Ion Channels and Disease (Quantitative Finance)|
|Format:||lit docx mobi rtf|
|ePUB size:||1244 kb|
|FB2 size:||1954 kb|
|DJVU size:||1938 kb|
|Publisher:||Academic Press; 1 edition (October 25, 1999)|
Frances M. Ashcroft (Author). ISBN-13: 978-0120653102. The book is richly illustrated with nt recordings of the relevant ion channels; hierarchical classification schemes for the relevant genes; tables listing locations of chromosomes, the distribution of various ion channels in tissue, mutations, and related protein abnormalities; and colored models based on crystal structures.
It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered
Author: Frances M. Ashcroft Publisher: Academic Press ISBN: 0080535216 Format: PDF, ePub, Docs Download Now Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function
Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Ion Channels and Disease - Frances M. Ashcroft.
Ion Channels and Disease. This Page Intentionally Left Blank. Ion Channels and Disease Channelopathies. Frances M. Ashcroft University Laboratory of Physiology Oxford, United Kingdom. San Diego London Boston New York Sydney Tokyo Toronto. 4 STUDYING ION CHANNELS Investigating Ion Channel Function 43 Potential Measurements 43 Voltage Clamp 44 Patch Clamp 46 Patch Clamp Configurations 47 Noise Analysis 49 Methods for Studying Intracellular Ion Channels 51 Obtaining the Primary Sequence 51 A Plethora of Enzymes 51 Cloning of Ion Channels 54 Functional Expression of Cloned Channels 55 Tissue Distribution 57 Investigating Ion Channel Structure 57 Topology 57. Mutational Analysis 59 Genetic Analysis of Ion Channels and Disease Chromosomal Location 60 Positional Cloning 61 Genetically Engineered Animals 64. Chapter.
Ion Channels and Disease: Channelopathies. Ion Channels and Disease: Channelopathies. Download (pdf, . 6 Mb) Donate Read.
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Ion Channels and Disease Close. 1 2 3 4 5. Want to Read. Are you sure you want to remove Ion Channels and Disease from your list? Ion Channels and Disease. by Frances M. Published January 15, 2000 by Academic Press. by: Ashcroft, Frances M. Publisher: Academic Press. Print ISBN: 9780120653102, 0120653109. Save up to 80% by choosing the eTextbook option for ISBN: 9780120653102, 9780080535210, 0080535216. The print version of this textbook is ISBN: 9780120653102, 0120653109.