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ISBN:0120653109
Author: Frances M. Ashcroft
ISBN13: 978-0120653102
Title: Ion Channels and Disease (Quantitative Finance)
Format: lit docx mobi rtf
ePUB size: 1244 kb
FB2 size: 1954 kb
DJVU size: 1938 kb
Language: English
Category: Medicine
Publisher: Academic Press; 1 edition (October 25, 1999)
Pages: 481

Ion Channels and Disease (Quantitative Finance) by Frances M. Ashcroft



Frances M. Ashcroft (Author). ISBN-13: 978-0120653102. The book is richly illustrated with nt recordings of the relevant ion channels; hierarchical classification schemes for the relevant genes; tables listing locations of chromosomes, the distribution of various ion channels in tissue, mutations, and related protein abnormalities; and colored models based on crystal structures.

It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered

Author: Frances M. Ashcroft Publisher: Academic Press ISBN: 0080535216 Format: PDF, ePub, Docs Download Now Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function

Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Ion Channels and Disease - Frances M. Ashcroft.

Ion Channels and Disease. This Page Intentionally Left Blank. Ion Channels and Disease Channelopathies. Frances M. Ashcroft University Laboratory of Physiology Oxford, United Kingdom. San Diego London Boston New York Sydney Tokyo Toronto. 4 STUDYING ION CHANNELS Investigating Ion Channel Function 43 Potential Measurements 43 Voltage Clamp 44 Patch Clamp 46 Patch Clamp Configurations 47 Noise Analysis 49 Methods for Studying Intracellular Ion Channels 51 Obtaining the Primary Sequence 51 A Plethora of Enzymes 51 Cloning of Ion Channels 54 Functional Expression of Cloned Channels 55 Tissue Distribution 57 Investigating Ion Channel Structure 57 Topology 57. Mutational Analysis 59 Genetic Analysis of Ion Channels and Disease Chromosomal Location 60 Positional Cloning 61 Genetically Engineered Animals 64. Chapter.

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Ion Channels and Disease: Channelopathies. Ion Channels and Disease: Channelopathies. Download (pdf, . 6 Mb) Donate Read.

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Ion Channels and Disease Close. 1 2 3 4 5. Want to Read. Are you sure you want to remove Ion Channels and Disease from your list? Ion Channels and Disease. by Frances M. Published January 15, 2000 by Academic Press. by: Ashcroft, Frances M. Publisher: Academic Press. Print ISBN: 9780120653102, 0120653109. Save up to 80% by choosing the eTextbook option for ISBN: 9780120653102, 9780080535210, 0080535216. The print version of this textbook is ISBN: 9780120653102, 0120653109.

Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies.Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features* Introduces the relevant aspects of molecular biology and biophysics* Describes the principal methods used to study channelopathies* Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function* Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
Reviews: 5
Gagas
Good overview of the various ion channels. Ashcroft is well respected in the biophysics and writes in an accessible manner.
Ttyr
A much needed textbook is now available for all neurologist and neuroscientist doing experiments in this field.
Modar
This is a fantastic book for anybody interested in ion channels or molecular medicine. If you happen to be a graduate student preparing for an exam in the field - this is your salvation! Personally, I read it with enormous delight. What a great compendium of this fascinating, quickly growing field! The style is very elegant, everything is lucid, the concepts come through crystal-clear. This was certainly an enormous amount of work and the book will be helpful to many in the field - for brushing up on channels that you don't work on, for checking things quickly, for teaching, and just for fun!
Blanche Schwappach, Howard Hughes Medical Institute, University of California, San Francisco
Winenama
This is a lucid discussion of the role of ion channels in disease. It begins with a wonderful introduction to molecular biology and physiology of ion channels suitable for neophyte as well as the seasoned investigator. Then individual ion and ligand gated channels are discussed in individual chapters. After the basic properties of each channel are introduced, diseases of the channels are discussed.
Gaeuney
This is really a landmark achievment to write such a good book in such a way, understandable .